A recent study reveals that people who stop using popular GLP-1 drugs like semaglutide or tirzepatide may regain shed pounds much more quickly than those who stop traditional diet and exercise programs.
Published data in a leading health publication points out that while overweight people frequently drop about a fifth of their total mass while on the medication, the mass returns at an average rate of 0.8 kg per month upon discontinuation.
"Individuals buying these drugs need to be aware of the potential of fast rebound weight gain when the therapy concludes," stated lead investigator Dr. Susan Jebb.
This pace of recovery implies a reversion to starting mass in about a year and a half.
Comparing Treatments
The analysis, which examined 37 of studies involving over 9,000 of participants, contrasted the results of the injectable medications with other pills.
The team note that individuals who lose weight through diet and exercise typically see a less rapid weight regain—approximately 100 grams monthly—once they finish.
The Reason for the Quick Regain
Experts suggest the mode of action of the injections accounts for the heightened rebound.
The injections imitate a body's own chemical called GLP-1, which moderates feelings of fullness.
"Long-term administration of GLP-1 concentrations far above than the body's typical production might result in the body to generate a reduced amount of its own natural hormone, and may also diminish responsiveness to its actions," noted Dr. Adam Collins, a dietetics researcher.
"Stopping of this hormone supplement means appetite is no longer kept in check, making binge eating much more probable."
An Ongoing Disease?
The NHS suggest the injections for people with obesity-related medical conditions, accompanied by prescribed lifestyle changes.
Many experts contend that, considering the likelihood of relapse, the therapy is often ongoing.
This view is echoed by drug manufacturers, who state that the results "highlight the chronic character of obesity," similar to managing conditions like high blood pressure.
Patient Testimonies
Individuals who have stopped the jabs describe a intense return of appetite.
"It felt as if a trigger flipping and I was suddenly starving," recalled one woman.
This challenge is compounded if patients have not adopted lasting lifestyle or habit changes during therapy.
Growing Adoption
Survey data suggest that a significant number of adults in the UK have used these injections in the last 12 months, with demand being substantial.
- Use is more common among females compared to males.
- The 40s and 50s age group shows the greatest usage rates.
- Many access the drugs through private healthcare rather than public health services.
Ultimately, researchers stress that while these medications are powerful agents for weight loss, they are not a standalone fix and lasting health benefits hinges on combined lifestyle management.
