RAF Typhoon FGR4s have operated alongside French warplanes in a joint strike against an subterranean weapons facility in Syria operated by the IS group, according to the British defence ministry.
The site, located using surveillance, was thought to be containing munitions and bombs, the release indicated, and was positioned in hills just above the historic site of Palmyra in central Syria.
"Our fighter planes utilized laser-guided Paveway IV weapons to target a number of access tunnels down to the site... early reports are that the strike was effective," the ministry announced.
There was no indication of any civilian casualties in the operation late on Saturday and each participating jet returned to base without incident, the defence officials confirmed.
The Typhoon FGR4s were backed up by a Voyager aerial refuelling aircraft.
The Islamic State group - referred to as Daesh - enforced extremist governance over parts of Syria and Iraq prior to its 2019 collapse.
"This action underscores our UK leadership, and resolve to work closely with allied nations, to eradicate any re-emergence of Daesh and their dangerous and violent ideologies in the area," Britain's Defence Chief the minister said.
RAF aircraft have performed surveillance missions over Syria to "forestall any attempted resurgence" of IS subsequent to its defeat at the climactic battle in Baghuz in the year 2019, the MoD reported.
"I must thank all the members of the UK armed forces involved in this operation for their professionalism and their valour," he said. "Including them were a great many British troops stationed over the holidays. This operation, to take out militants who pose a risk to our security, highlights how UK forces are prepared to act, throughout the year, protecting the UK domestically and powerful internationally."
During December, the American forces executed what it described as a "major assault" on IS targets in the country, following an ambush resulted in the deaths of two US servicemembers and a civilian interpreter in Palmyra.
The United Nations says IS still maintains between 5,000 and 7,000 militants in Syria and Iraq.
